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Oct 10

About NT-proBNP.

About NT-proBNP.NTproBNP is widely recognized as a marker for the definitive diagnosis of HF In the United Statesis from the precursor peptide proBNP in quantities directly proportional cleaved to its biologically active counterpart BNP and in close correlation with the severity from heart failure. BNP is primarily of the left ventricle in response to pressure overload secreted and regulates blood pressure, electrolyte balance, and fluid volume. BNP Elevated levels of reduce the pressure overload. Elevated levels of NT-proBNP indicate the presence of heart failure, and provide physicians with an important diagnostic tool in the early detection and management of HF.

The prevalence of HF is expected to increase due to the aging population and improved survival rates of patients with other cardiovascular diseases.

The report, the increase in the supply of donor organs in the European Union , is in the details on the Communication of the European Commission in May 2007, according to this the a number of suggestions for actions at Community and national level in order to provide look to increase donor organs in the EU.. About HF – RF the ability of the heart, blood hampered to a rate sufficient vital needs pump. HF affects nearly 17 million people worldwide and is the single most common cause of hospitalization in people over 65 years. The first diagnosis of HF is problematic as symptoms with other illnesses such as respiratory diseases and the side effects of obesity may be associated.Repair SUMO two thirds Required cell damagethat RPA70 with SUMO two thirds recruit RAD51, an important protein to the modifies. DNA lesions DNA damage by homologous recombination when is a mutant which is not substituted to SUMOylated to RPA70, repair is defective, which the cell is an increased susceptibility to camptothecin and radiation.

Tearing ‘For double-stranded DNA losses damage It must repair SUMO two thirds to be there for repairing appear effectively, ‘Yeh said. ‘RPA70 is a crucial protein in both for DNA replication and service, and his relationship to its relationship to DNA repair and why do SUMO is important for of these processes ‘. The funding of this work has been which NIH.