Sep 25

Abnormal protein translation leads to Fragile X ataxia.

The gene mutation that causes FXTAS is certainly a repeated DNA sequence that is made into RNA but normally is not made into protein because it lacks a start codon. However, the investigators found that when this do it again expands, it could trigger protein production by a new mechanism referred to as RAN translation. Corresponding author Peter Todd, M.D., Ph.D., notes that this unusual translation process seems to stem from an extended chain of repeated DNA ‘letters’ within the genes of both grandparents and children with Fragile X mutations.Kaiser Health Information, an editorially independent news service, is a scheduled system of the Kaiser Family members Foundation, a nonpartisan health care policy research business unaffiliated with Kaiser Permanente.. Alcohol-related deaths increasing worldwide Approximately 3. 3 million deaths world-wide in 2012 were the total consequence of alcohol consumption, according to a new report from the global world Health Organization. Additionally, 16 % of individuals in the globe who use alcohol could possibly be categorized as binge drinkers. The new survey, which examined the trends in alcohol make use of among 194 WHO member states, found European countries topped the list for the region with the highest rate of alcohol intake per capita, although rate has remained stable in the last five years.